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News: Chromtech Chiral HPLC Columns

Article Date(s):01/09/2012 - 01/09/2012

Chiral HPLC columns

These protein-based columns are suitable for several types of compounds; basic compounds can be separated on both CHIRAL-AGP and CHIRAL-CBH, acidic and neutral compounds can be separated on both CHIRAL-AGP and CHIRAL-HSA. However, as CHIRAL-AGP is a column with an extremely broad applicability, this column should be chosen first, if the analyte has not been separated on any of the columns. There are, however, some types of compounds where one of the other columns may be the first choice :

  • CHIRAL-AGP

Extremely broad applicability. We believe that this chiral phase as one of the broadest analytical selectivities of any chiral phase. Separates all kinds of compounds :

    • amines (primary, secondary, tertiary and quartenary)
    • acids (strong and weak)
    • nonprotolytes (amides, esters, alcohols)
       
  • CHIRAL-CBH

Narrower applicability than CHIRAL-AGP. Separates compounds containing one or more basic nitrogens together with one or more basic nitrogens together with one or more hydrogen accepting or hydrogen donating groups (alcohol, phenol, carbonyl, amide, ether, sulphoxide, ester, etc.).

  • CHIRAL-HSA

Narrower applicability than CHIRAL-AGP. Separates preferentially weak and strong acids and non-protolytic compounds.


Chiral-HSA

The chiral selector in this stationary phase is human serum albumin (HSA). The protein has been immobilized onto spherical 5μm particles. Enantiomers of preferentially acidic compounds can be resolved directly, without derivatization. The column is operated in the reverse phase mode. With the Chiral-HSA column, both racemic acids and amino acids can be resolved directly, without derivatization.

 

CHROMTECH CHIRAL-HSA

Ref.Product NameColumn Length (mm)Internal Diameter (mm)Particle Size (µm)Product Type
CHROMTECH CHIRAL-HSA COLUMNS 5 µm
34713CHIRAL-HSA10045Analytical
34714CHIRAL-HSA15045Analytical
34712CHIRAL-HSA5045Analytical
34783CHIRAL-HSA10035Analytical
34784CHIRAL-HSA15035Analytical
34782CHIRAL-HSA5035Analytical
34793CHIRAL-HSA10025Analytical
34794CHIRAL-HSA15025Analytical
34792CHIRAL-HSA5025Analytical
34733CHIRAL-HSA100105Semi-Prep
34734CHIRAL-HSA150105Semi-Prep
34781CHIRAL-HSA (2/pkg)1035Guard Cartridges (x2)
34791CHIRAL-HSA (2/pkg)1025Guard Cartridges (x2)
34711CHIRAL-HSA (2/pkg)1045Guard Cartridges (x2)




Chiral-CBH

Cellobiohydrolase (CBH) is a stable enzyme which has been immobilized onto 5 μm spherical silica particles creating the Chiral Stationary Phase in the Chiral-CBH column. This is also a reverse phase column, used for the direct separation of enantiomers. The column is preferentially used for the separation of the enantiomers of basic drugs from many compound classes.

 

CHROMTECH CHIRAL-CBH

Ref.Product NameColumn Length (mm)Internal Diameter (mm)Particle Size (µm)Product Type
CHROMTECH CHIRAL-CBH COLUMNS 5 µm
33713CHIRAL-CBH10045Analytical
33714CHIRAL-CBH15045Analytical
33712CHIRAL-CBH5045Analytical
33783CHIRAL-CBH10035Analytical
33784CHIRAL-CBH15035Analytical
33782CHIRAL-CBH5035Analytical
33793CHIRAL-CBH10025Analytical
33794CHIRAL-CBH15025Analytical
33792CHIRAL-CBH5025Analytical
33733CHIRAL-CBH100105Semi-Prep
33734CHIRAL-CBH150105Semi-Prep
33781CHIRAL-CBH (2/pkg)1035Guard Cartridges (x2)
33791CHIRAL-CBH (2/pkg)1025Guard Cartridges (x2)
33711CHIRAL-CBH (2/pkg)1045Guard Cartridges (x2)







Chiral-AGP

CHIRAL-AGP is the second generation chiral separation column based on the use of α1-acid glycoprotein (AGP) as the CSP. Through a patented process α1-AGP has been immobilized on porous, spherical silica particles (5μm). The surface chemistry of the silica proves a stable chiral separation material with extremely broad applicability.

ENANTIOSELECTIVITY

Racemic amines, acids and nonprotolytic compounds can be resolved directly, without derivatization. The column enables resolution of a very large number of chiral compounds from different compound classes. This is due to the unique nature of the CSP, and the fact that enantioselectivity can be induced by choosing a proper mobile phase composition.

 

CHROMTECH CHIRAL-AGP

Ref.Product NameColumn Length (mm)Internal Diameter (mm)Particle Size (µm)Product Type
CHROMTECH CHIRAL-AGP COLUMNS 5 µm
30713CHIRAL-AGP10045Analytical
30714CHIRAL-AGP15045Analytical
30712CHIRAL-AGP5045Analytical
30783CHIRAL-AGP10035Analytical
30784CHIRAL-AGP15035Analytical
30782CHIRAL-AGP5035Analytical
30793CHIRAL-AGP10025Analytical
30794CHIRAL-AGP15025Analytical
30792CHIRAL-AGP5025Analytical
30733CHIRAL-AGP100105Semi-Prep
30734CHIRAL-AGP150105Semi-Prep
30781CHIRAL-AGP (2/pkg)1035Guard Cartridges (x2)
30791CHIRAL-AGP (2/pkg)1025Guard Cartridges (x2)
30711CHIRAL-AGP (2/pkg)1045Guard Cartridges (x2)

 

ACCESSORIES FOR CHROMTECH COLUMNS

Ref.
Product Name
Particule Size (µ)
Product Type
00081
GUARD CARTRIDGE HOLDER
\
HOLDER FOR GUARD CARTRIDGE
CG000D1
GUARD COLUMN COUPLER (4 mm) I.D.
\
COUPLER
CG000D2
GUARD COLUMN COUPLER MICRO (3 mm, 2 mm) I.D.
\
COUPLER

 

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